Projects

Research activity at Gustincich's Laboratory of Neurogenomics is organized in the following projects:

1.    Blood transcriptomics of Parkinson's Disease. 
2.    The transcriptional landscape of dopaminergic cells.
3.    The function of Hemoglobin in dopaminergic cells.
4.    SINEUPS: a new functional class of long non-coding RNAs.
5.    RNA therapeutics.
6.    The role of repetitive elements in brain function.

Blood transcriptomics of Parkinson's Disease

Blood transcriptomics represents a powerful tool to characterize the systemic status of an individual in health and disease...

The transcriptional landscape of dopaminergic cells

Gene expression profiling of dopaminergic neurons of the Substantia Nigra is correlated to selective cellular susceptibility in Parkinson's Disease (PD)…

The function of Hemoglobin in dopaminergic cells

Hemoglobin is unexpectedly expressed in dopaminergic neurons of the Substantia Nigra. Its function is under investigation…

SINEUPs: a new functional class of long non-coding RNAs

In the Laboratory of Neurogenomics, scientists identified a new functional class of natural and synthetic long non-coding RNAs that has been called SINEUP since, by the function of a SINE sequence, these RNAs are able to UP-regulate translation of sense mRNAs...

RNA therapeutics

Synthetic SINEUPs may be targeted to genes involved in haploinsufficiencies to increase protein synthesis for RNA therapeutics…

The role of repetitive elements in brain function

Retrotransposons may shape intra-individual neuronal genome variants in mammalian brain…

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