Publications

  • 75 peer-reviewed publications among research articles and reviews
  • total IF >700
  • average IF >10
  • h index of 26 (Scopus, Apr 2014)
  • total citations >5000  (Scopus, Apr 2014)

View PUBLICATIONS on PubMed.

An atlas of active enhancers across human cell types and tissues

Journal: 

Nature 507(7493): 455-61 doi:10.1038/nature12787

Date: 

27 March, 2014

Enhancers control the correct temporal and cell-type-specific activation of gene expression in multicellular eukaryotes. Knowing their properties, regulatory activity and targets is crucial to understand the regulation of differentiation and homeostasis. Here we use the FANTOM5 panel of samples, covering the majority of human tissues and cell types, to produce an atlas of active, in vivo-transcribed enhancers.

A promoter-level mammalian expression atlas

Journal: 

Nature 507(7493): 462-70 doi:10.1038/nature13182

Date: 

27 March, 2014

Regulated transcription controls the diversity, developmental pathways and spatial organization of the hundreds of cell types that make up a mammal. Using single-molecule cDNA sequencing, we mapped transcription start sites (TSSs) and their usage in human and mouse primary cells, cell lines and tissues to produce a comprehensive overview of mammalian gene expression across the human body.

NanoCAGE analysis of the mouse olfactory epithelium identifies the expression of vomeronasal receptors and of proximal LINE elements

Journal: 

Front Cell Neurosci 8:41

Date: 

18 February, 2014

By coupling laser capture microdissection to nanoCAGE technology and next-generation sequencing we have identified the genome-wide collection of active promoters in the mouse Main Olfactory Epithelium (MOE). Transcription start sites (TSSs) for the large majority of Olfactory Receptors (ORs) have been previously mapped increasing our understanding of their promoter architecture. Here we show that in our nanoCAGE libraries of the mouse MOE we detect a large number of tags mapped in loci hosting Type-1 and Type-2 Vomeronasal Receptors genes (V1Rs and V2Rs).

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